Interactive situation modelling in knowledge intensive domains

Interactive Situation Modelling (ISM) method, a semi-methodological approach, is proposed to tackle issues associated with modelling complex knowledge intensive domains, which cannot be easily modelled using traditional approaches. This paper presents the background and implementation of ISM within a complex domain, where synthesizing knowledge from various sources is critical, and is based on the principles of ethnography within a constructivist framework. Although the motivation for the reported work comes from the application presented in the paper, the actual scope of the paper covers a wide range of issues related to modelling complex systems. The author firstly reviews approaches used for modelling knowledge intensive domains, preceded by a brief discussion about two main issues: symmetry of ignorance and system behaviour, which are often confronted when applying modelling approaches to business domains. The ISM process is then characterized and critiqued with lessons from an exemplar presented to illustrate its effectiveness

B-cell Prolymphocytic Leukemia in a Young Male

B-cell prolymphocytic leukemia [B-PLL] is a neoplasm of B prolymphocytes affecting the peripheral blood, bone marrow and spleen. The principal disease characteristics are massive splenomegaly with absent or minimal peripheral lymphadenopathy and a rapidly rising lymphocyte count. Here, we report a case of B-PLL in a 42 year old male who had come for routine health check up

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis

Chondroid Syringoma and Eccrine Spiradenoma

Fine needle aspiration cytology (FNAC) is a well established diagnostic tool. However, most clinicians prefer to diagnose suspected skin tumors by excisional biopsy as they are easily accessible and hence benign skin adnexal tumors are rarely encountered on FNAC. There are only a very few case reports describing the fine needle aspiration cytologic features of chondroid syringoma and eccrine spiradenoma for diagnosis. Cases: First case was a 20 year old female who presented with firm,non-tender swelling in the left little finger measuring 1 cm in diameter. Smears showed clusters of round to plasmacytoid cells with moderate to abundant cytoplasm embedded in a chondromyxoid ground substance . Hence, a diagnosis of chondroid syringoma was made. Another case was a 40 year old lady who presented with a painful swelling on the anterior chest wall measuring approximately 0.8 cms in diameter. Smears were moderately cellular with cohesive sheets and clusters of bland cells of three different cell types. Hence, a probable diagnosis of eccrine spiradenoma was made and both the cases were confirmed histologically. Conclusion: Appropriate knowledge of the cytologic features of chondroid syringoma and eccrine spiradenoma helps in providing a definitive diagnosis and correct management of the patient

Variação da produtividade do arroz de terras altas influenciados pela seca meteorológica em Goiás.

A seca é um fenômeno meteorológico caracterizado pela falta de precipitação pluvial, que pode causar grandes prejuízos à produção agrícola. O presente trabalho tem como objetivo caracterizar a ocorrência de seca, utilizando o Índice Padronizado de Precipitação (SPI) em cinco microrregiões do estado de Goiás e sua influencia na produtividade de arroz de terras altas. As cinco microrregiões estudadas foram: Anápolis, Ceres, Iporá, Anicuns e Goiânia. A série de dados históricos de precipitação foi disponibilizada pela Agência Nacional de Águas (ANA), coletados em um município pertencente à microrregião analisada. O período de estudo foi de 1975 a 2005. Os dados de produtividade, para o mesmo período foi disponibilizado pela AGROTEC. Os valores do SPI foram caracterizados pela a ocorrência dos eventos de seca, frequência relativa, comparação com os dados de produtividade do arroz de terras altas e o percentual de acerto do índice. Foi possível observar que o SPI não acompanhou totalmente a variação da produtividade do arroz de terras altas. O SPI apresentou percentuais de acerto baixos, em todas as microrregiões, ficando próximo a 51%